Synthesis, characterization and applications of densely functionalized pyridazines and fulvene-type compounds containing azulene moiety

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Title:	Synthesis, characterization and applications of densely functionalized pyridazines and fulvene-type compounds containing azulene moiety
Authors:	Badugu Devendar;Chi-Phi Wu;Chi-Yuan Chen;Hung-Chang Chen;Chung-Hao Chang;古建國;Chien-Kuo Ku;Cheng-Yin Tsai;Chieh-Yuan Ku
Contributors:	臺北市立教育大學應用物理暨化學學系暨碩士班
Keywords:	Azulene;Vilsmeier-Haack formylation;Friedel–Crafts reaction;Michael addition reaction;Intramolecular cyclization
Date:	2013-06
Issue Date:	2013-12-27 18:09:58 (UTC+8)
Abstract:	Ethyl 4-ethoxyazulene-1-carboxylate (1) is highly efficient and novel substrate for electrophilic substitution reactions. These derivatives (2-4) were treated with NH2NH2/PhNHNH2 in ethanol to produce pyridazine, and fulvene derivatives with azulene frameworks (5, 6, 17, 19) via intramolecular cyclization. The substrates 5-8, 11, and 19 were effectively converted into densely functionalized heterocyclic molecules via Vilsmeier-Haack, Friedel-Crafts, and Michael addition reactions.
Relation:	Tetrahedron，Vol. 69,Issue 24，Pages 4953-4963
Appears in Collections:	[Department of Applied Physics and Chemistry] Periodical Articles

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