Metabolomics of Children and Adolescents Exposed to Industrial Carcinogenic Pollutants

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Title:	Metabolomics of Children and Adolescents Exposed to Industrial Carcinogenic Pollutants
Authors:	CC, Chen CS； Kuo TC； Kuo HC； Tseng YJ； Kuo CH；Yuan TH；袁子軒； Chan
Contributors:	衛生福利學系
Keywords:	Biomarkers；Cancer；Metabolism；Oxidative stress；Toxicology
Date:	2019
Issue Date:	2023-08-28 10:21:17 (UTC+8)
Abstract:	Studies on metabolomes of carcinogenic pollutants among children and adolescents are limited. We aim to identify metabolic perturbations in 107 children and adolescents (aged 9–15) exposed to multiple carcinogens in a polluted area surrounding the largest petrochemical complex in Taiwan. We measured urinary concentrations of eight carcinogen exposure biomarkers (heavy metals and polycyclic aromatic hydrocarbons (PAHs) represented by 1-hydroxypyrene), and urinary oxidative stress biomarkers and serum acylcarnitines as biomarkers of early health effects. Serum metabolomics was analyzed using a liquid chromatography mass spectrometry-based method. Pathway analysis and “meet-in-the-middle” approach were applied to identify potential metabolites and biological mechanisms linking carcinogens exposure with early health effects. We found 10 potential metabolites possibly linking increased exposure to IARC group 1 carcinogens (As, Cd, Cr, Ni) and group 2 carcinogens (V, Hg, PAHs) with elevated oxidative stress and deregulated serum acylcarnitines, including inosine monophosphate and adenosine monophosphate (purine metabolism), malic acid and oxoglutaric acid (citrate cycle), carnitine (fatty acid metabolism), and pyroglutamic acid (glutathione metabolism). Purine metabolism was identified as the possible mechanism affected by children and adolescents’ exposure to carcinogens. These findings contribute to understanding the health effects of childhood and adolescence exposure to multiple industrial carcinogens during critical periods of development.
Relation:	Environmental Science & Technology,v.53n.9,p.5454-5465
Appears in Collections:	[Department of Health and Welfare] Articles

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