| 題名: | Maximum number of live births per donor in artificial insemination |
| 作者: | Charlotte Wang
Miao-Yu Tsai
Mei-Hsien Lee
Su-Yun Huang
Chen-Hung Kao
Hong-Nerng Ho
Chuhsing Kate Hsiao
李美賢
蔡秒玉
黃素雲
何弘能
蕭朱杏 |
| 貢獻者: | 臺北市立教育大學數學資訊教育學系 |
| 關鍵詞: | artificial insemination by donor
assortative mating
coefficient of inbreeding
consanguinity
hereditary disease |
| 日期: | 2007 |
| 上傳時間: | 2009-08-04 10:54:21 (UTC+8) |
| 摘要: | BACKGROUND: The maximal number of live births (k) per donor was usually determined by cultural and social perspective. It was rarely decided on the basis of scientific evidence or discussed from mathematical or probabilistic viewpoint.
METHODS AND RESULTS: To recommend a value for k, we propose three criteria to evaluate its impact on consanguinity and disease incidence due to artificial insemination by donor (AID). The first approach considers the optimization of k under the criterion of fixed tolerable number of consanguineous mating due to AID. The second approach optimizes k under fixed allowable average coefficient of inbreeding. This approach is particularly helpful when assessing the impact on the public, is of interest. The third criterion considers specific inheritance diseases. This approach is useful when evaluating the individual's risk of genetic diseases. When different diseases are considered, this criterion can be easily adopted. All these derivations are based on the assumption of shortage of gamete donors due to great demand and insufficient supply.
CONCLUSIONS: Our results indicate that strong degree of assortative mating, small population size and insufficient supply in gamete donors will lead to greater risk of consanguinity. Recommendations under other settings are also tabulated for reference. A web site for calculating the limit for live births per donor is available. |
| 關聯: | HUMAN REPRODUCTION, V22(5), p.1363-1372 |
| 顯示於類別: | [數學系(含數學教育碩士班)] 期刊論文
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