The aim of this study was to develop a multi-user game-based system, called Kala-Forest, for children with chronic illness. Three eight-year-old children with leukemia participated. In the first phase, children create their own or co-construct narratives and play games in the single-mode digital game-based learning. Then, we
developed the multi-mode Monopoly board game to integrate Kala-Forest and other digital game-based learning activities. The results supported that the multi-mode of digital game-based learning provided the social interactive processes, which effectively served the psychosocial needs for chronically ill children.